N-(m-PEG4)-N'-(azide-PEG4)-Cy7 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

Product information

CAS Number: 2107273-40-3

Molecular Weight: 852.50

Formula: C46H66ClN5O8

Chemical Name: 2-[(1E,3E,5E)-7-[1-(14-azido-3,6,9,12-tetraoxatetradecan-1-yl)-3,3-dimethyl-2,3-dihydro-1H-indol-2-ylidene]hepta-1,3,5-trien-1-yl]-3,3-dimethyl-1-(2,5,8,11-tetraoxatridecan-13-yl)-3H-indol-1-ium chloride

Smiles: [Cl-].COCCOCCOCCOCC[N+]1C2=CC=CC=C2C(C)(C)C=1/C=C/C=C/C=C/C=C1N(CCOCCOCCOCCOCCN=[N+]=[N-])C2=CC=CC=C2C1(C)C

InChiKey: ISHBUBOOHQEWKB-UHFFFAOYSA-M

InChi: InChI=1S/C46H66N5O8.ClH/c1-45(2)39-15-11-13-17-41(39)50(22-25-54-30-33-58-36-35-56-28-27-52-5)43(45)19-9-7-6-8-10-20-44-46(3,4)40-16-12-14-18-42(40)51(44)23-26-55-31-34-59-38-37-57-32-29-53-24-21-48-49-47;/h6-20H,21-38H2,1-5H3;1H/q+1;/p-1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Products are for research use only. Not for human use.