Recombinant Mouse CNDP2/CPGL/PEPA Protein (His Tag)

Sizes: 10μg, 50μg

Catalogue Numbers: PKSM041231-10, PKSM041231-50

Citations, Manuals and MSDS Available upon request.

Abbreviation: CNDP2; CPGL; PEPA

Target Synonym: CNDP2; CNDP dipeptidase 2; Cytosolic non-specific dipeptidase; Glutamate carboxypeptidase-like protein 1; Dip-2; Pep-1; Pep1

Target Species: Mouse

Expression Host: HEK293 Cells

Fusion Tag: C-6His

Accession: NP_075638.2

Background: Mouse cytosolic non-specific dipeptidase(CNDP2) is a cytoplasm protein which belongs to the peptidase M20A family. CNDP2 has 2 Isoform: Isoform 1 is ubiquitously expressed with higher levels in kidney and liver (at protein level). Isoform 2 is expressed in fetal tissues, it is only expressed in adult liver and placental tissues. CNDP2 hydrolyzes a variety of dipeptides including L-carnosine and has a strong preference for Cys-Gly. It is a cytosolic enzyme that can hydrolyze carnosine to yield l-histidine and beta-alanine. CNDP2 is highly expressed in the histaminergic neurons in the tuberomammillary nucleus, implying that it may supply histidine to histaminergic neurons for histamine synthesis. It may play a role as tumor suppressor in hepatocellular carcinoma (HCC) cells.

Sequence: Met1-Asn475

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH8.0.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Not Applicable

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 53.8 kDa

Observed MW: 56-60 kDa

Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Research Use Only